男性45岁时某些类型的脱发是患有前列腺癌的危险征兆

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American Society ofClinical Oncology (ASCO)

美国临床肿瘤协会(ASCO)

New, large cohortanalysis from the prospective Prostate, Lung, Colorectal and Ovarian (PLCO)Cancer Screening Trial, indicates that men who had moderate baldness affectingboth the front and the crown of their head at age 45 were at a 40% increasedrisk of developing aggressive prostate cancer (usually indicates a fastergrowing tumor resulting in poorer prognosis relative to non-aggressive prostatecancer) later in life, compared to men with no baldness. There was nosignificant link between other patterns of baldness and prostate cancer risk.The study, published September 15 inthe Journal of Clinical Oncology, supports earlier research suggesting thatmale pattern baldness and prostate cancer may be linked.

一个新的，大型的潜在前列腺癌、肺癌、大肠癌和卵巢癌临床试验筛选断代分析表明，前额和头顶头发在46岁时不断掉落的男性与没有脱发的男性相比，以后患有侵略性前列腺癌的可能性增加40%（通常意味着没有很好地诊断出非侵略性前列腺癌而造成的肿瘤的快速扩张），而别的部位脱发则与患前列腺癌的风险没有太大的关联。这篇发表在9月15出版的《临床肿瘤学》上的文章证实了之前的研究结果，认为男性某种类型脱发可能与前列腺癌有关。

"Our study found anincreased risk for aggressive prostate cancer only in men with a very specificpattern of hair loss, baldness at the front and moderate hair-thinning on thecrown of the head, at the age of 45. But we saw no increased risk for any formof prostate cancer in men with other hair-loss patterns," said seniorstudy author Michael B. Cook, PhD, an investigator in the Division of CancerEpidemiology and Genetics at the National Cancer Institute in Bethesda, MD."While our data show a strong possibility for a link between thedevelopment of baldness and aggressive prostate cancer, it's too soon to applythese findings to patient care."

“我们的研究发现，只有某些特性类型的脱发，头前面和头顶的头发在45岁时开始脱落，患侵略性前列腺癌的可能性增加。而其他类型的脱发则与患前列腺癌的风险关系不大，”位于马里兰州贝塞斯达的美国国家癌症研究所肿瘤流行病学和遗传学部门的高级研究员、本文作者迈克尔·b·库克博士说。“虽然我们的数据表明持续脱发很可能与侵略性前列腺癌有关联，但将这个发现应用于病人护理还为时尚早。”

Prostate cancer is thesecond most common cancer among men. Emerging evidence suggests that prostatecancer and male pattern baldness -- progressive scalp hair-loss in a distinctpattern -- are both connected to increased levels of male sex hormones(androgens) and androgen receptors, supporting the idea of a biological linkbetween baldness and prostate cancer development and progression.

前列腺癌是男性第二大常见癌症。新出现的证据表明前列腺癌和男性某种类型的脱发—以一种特定的模式持续掉发—与男性性激素(androgens)和性激素受体的水平增加都有关联，表明脱发与前列腺癌的发展和恶化存在着生物关联。

Researchers analyzed malepattern baldness in relation to prostate cancer risk in a cohort of 39,070 menfrom the U.S. PLCO Cancer Screening Trial, aged 55-74 years at enrollment. Themen received a questionnaire that asked them to recall what their hair-losspatterns were at age 45 using a pictorial tool.

研究人员对进行了美国前列腺癌临床试验筛选的，登记在册的，55到74岁的3万9070名男性进行了男性某种类型脱发与患前列腺癌的关联进行了分析。这些男性接受了问卷调查，通过图形工具回忆他们在45岁时的脱发类型。

During follow-up, 1,138prostate cancer cases were diagnosed, 51% of which were aggressive (Gleasonscore equal to or greater than 7, stage III or IV, or prostate cancer as thecause of death). The mean age at the time of prostate cancer diagnosis was 72.

接下来的随访表明，前列腺癌的确诊病例的1138例，其中51%为侵略性的（格里森评分等于或大于7,III期或IV期，或因前列腺癌病死）。诊断出前列腺癌的平均年龄为72岁。

Men who had a specificpattern of baldness, frontal and moderate crown (vertex), were 40% more likelyto develop aggressive prostate cancer, compared to men who had no baldness.There was no association between male pattern baldness and risk ofnon-aggressive prostate cancer.

前额和头顶头发在46岁时不断掉落的男性与没有脱发的男性相比，以后患有侵略性前列腺癌的可能性增加40%。而别的部位脱发则与患前列腺癌的风险没有太大的关联

Dr. Cook stated that ifthese findings are confirmed by further studies, medical assessment of baldnesscould possibly be used to help identify men who may be at increased risk ofaggressive prostate cancer. His research team is currently conducting twoadditional cohort analyses exploring the relationship between male patternbaldness and risk of developing and dying from prostate cancer. One of thestudies includes a baseline dermatologic assessment of male pattern baldness,which may be more reliable than the recall method, which was used in thepresent study. This research was supported by the intramural program of theU.S. National Cancer Institute, National Institutes of Health.

库克博士认为如果这个发现被进一步的研究所证实，那么脱发医疗审定可用来帮助识别患前列腺癌可能性增加的男性。他的研究团队目前正在实施两个补充的断代分析，探索男性某种类型的脱发与前列腺癌发展和恶化之间的联系。其中一个研究包括模式脱发的头皮层发根评估，这比目前研究中使用的依靠回忆要可靠地多。此研究得到了美国国立卫生研究院、美国国家肿瘤研究所内部项目的资助。