A matter of life and death CONCEPTION and cancer, which mark the beginning and, often, the end of life, share some molecular details. Cancer cells copy their contents and divide rapidly; so do newly fertilized eggs. This requires genetic reprogramming. Curiously, as a result of the reprogramming, both contain appreciable amounts of an enzyme called reverse transcriptase that biologists more usually associate with certain viral infections, including HIV. Reverse transcriptase makes part of the cells protein publishing line work backwards, recreating DNA, a molecule in which organisms typically store genetic information, from its less stable and correspondingly less favoured cousin, RNA. Why it does so in cancer and in embryos, though, is something of a mystery. Corrado Spadafora, of Italys National Institute of Health, in Rome, studies this little-known puzzle. There are thousands of reverse-transcriptase genes in the genomes of all mammals. What that job is exactly, Dr Spadafora is not sure, but data he presented at the annual meeting of the British Andrology Society, in Leeds, suggest some answers. Dr Spadafora showed recently that reverse transcriptase is required for mouse embryos to develop. He did this by removing it in two ways. First, he exposed embryos created in Petri dishes to a common AIDS drug called nevirapine, which works by gumming the enzyme up. This halted development whenever it was added to embryos up to the stage when they were only four cells big. Adding the drug later, when the four cells had divided into eight, had no effect. Second, he checked the drug was not bad for the embryos in some other, unknown, way by specifically turning off reverse transcriptase-producing genes. The result was the same: the embryos did not die, and again, during the sensitive period, they seemed to get stuck in a juvenile stage. There are hints that reverse transcriptase is needed for a lot of early embryonic functions associated with getting cells ready to specialize into different types of tissue. Seven of the ten genes Dr Spadafora tested were active in healthy embryos, but were shut down in the nevirapine arrested ones. Since cancer cells also contain a lot of reverse transcriptase, Dr Spadafora wondered whether stopping the enzyme working might stop them dividing as well. He transplanted four kinds of human cancer into four groups of mice and treated some of each group with nevirapine or a similar drug. In all cases the earlier he gave the drug, the slower the tumours grew, and they always grew more slowly than tumours in mice which got neither drug. As in the embryo experiments, he then silenced the cancer-cell genes that produced reverse transcriptase, and likewise found the tumours grew more slowly. Moreover, both the drugs and the gene-silencing technique flattened some types of cancer cells, which suggests that both methods of getting rid of reverse transcriptases effects caused similar molecular changes inside the cells. That common anti-HIV drugs slow cancer growth in AIDS patients has been known for some time. Doctors, however, have attributed the fact to the healthier immune systems the drugs promote. Dr Spadaforas results suggest a more precise mechanism. 1. According to the first paragraph, cancer cells and newly fertilized eggs are similar to each other in the following aspects except that . A. both of them copy their contents and divide quickly B. both of them genetic information of organisms C. both of their division involves genetic reprogramming D. both of them contain reverse transcriptase 2. Reverse transcriptase can . A. recreate DNAs cousin RNA B. make the cells protein publishing line work C. flatten some cancer cells D. recreate DNA 3. What is the most important achievement of Corrado Spadaforas experients? A. Reverse transcriptase is necessary for embryos to develop. B. Getting rid of reverse transcriptases effects change the cells. C. Common anti-HIV drugs are effective to cure cancer. D. A more precise mechanism is suggested to promote the healthier immune systems. 4. The word them refer to . A. cancer cells B. reverse transcriptase C. the enzyme D. healthy embryos 5. How can we slow the growth of tumors? A. create more reverse transcriptase B. use nevirapine as late as possible C. silence the cancer-cell genes D. promote cells dividing 考研词汇 molecular a.分子的,由分子组成的 [真题例句] But NBAC members are planning to word the recommendation narrowly to avoid new restrictions on research that involves the cloning of human DNA or cells-routine in molecular biology.[1999年阅读4] [例句精译] 但是,NBAC成员们正计划在建议的措辞上更为严谨,以避免给克隆人体DNA或细胞等研究带来更多地限制分子生物研究中的常规课题。 reverse n.①相反,反转,颠倒;②背面,后面;a.相反的,倒转的;v.颠倒,倒转,倒退 [真题例句] Anyone can see this trend is unsustainable.Yet few seem willing to try to reverse it.[2003年阅读4] [例句精译] 任何人都明白这个趋势不能维持下去,但是很少有人愿意扭转它。 expose v.①使暴露,受到;②使曝光;③揭露 [真题例句] Owing to the remarkable development in mass-communications, people everywhere are feeling new wants and are being exposed to new customs and ideas, while governments are often forced to introduce still further innovations for the reasons given above.[2000年翻译] [例句精译] 大众通讯的显著发展使各地的人们不断感到有新的需求,不断接触到新的习俗和思想,由于上述原因,政府常常得推出更多的革新。 juvenile a.青少年的,幼稚的;n.青少年,少年读物 [真题例句] Many theories concerning the causes of juvenile Delinquency focus either on the individual or on society as the major contributing influence.[2004年完形] [例句精译] 有关少年犯罪的许多理论往往将其主要原因归咎于个人或社会. immune a.①免疫的,有免疫力的;②有受影响的;③免除的,豁免的 [真题例句] The rats bacterial infections of the blood , their immune systemsthe self-protecting mechanism against diseasehad crashed.[1995年完形] [例句精译] 老鼠患血液细菌感染,似乎它们的免疫系统抵御疾病的自我保护机制已崩溃。 precise a.精确的,准确的 [真题例句] Much of the language used to describe monetary policy, such as steering the economy to a soft landing or a touch on the brakes, makes it sound like a precise science.[1997年阅读5] [例句精译] 很多用来描述货币政策的词,如引导经济软着陆,经济刹车,使货币政策听起来像是一门精确的科学。
2015考研英语阅读入侵物种繁衍与湮灭
2015考研英语阅读日本的手机游戏业
2015考研英语阅读腹地美景
2015考研英语阅读猎手与猎物
2015考研英语阅读远未结束
2015考研英语阅读定制宠物
2015考研英语阅读油价
2015考研英语阅读种族广告
2015考研英语阅读以整体思维设计欧洲债券
2015考研英语阅读金色降落伞
2015考研英语阅读为股票做广告
2015考研英语阅读硅谷知识产权之争
2015考研英语阅读太阳能关税
2015考研英语阅读重塑皮拉马尔
2015考研英语阅读身为人父的喜悦
2015考研英语阅读俄罗斯服装世界
2015考研英语阅读比尔克林顿的忠告
2015考研英语阅读合作关系的演变
2015考研英语阅读简单的输血
2015考研英语阅读索尼管理权重回日本人手里
2015考研英语阅读商业与地缘政治学
2015考研英语阅读教授们的Facebook
2015考研英语阅读人造肉
2015考研英语阅读听起来很美
2015考研英语阅读窃听风暴
2015考研英语阅读制药商和抗生素
2015考研英语阅读拼拼凑凑见真相
2015考研英语阅读科学出版信息的价格
2015考研英语阅读关节炎与肉毒杆菌
2015考研英语阅读解密达芬奇密码
| 不限 |
| 英语教案 |
| 英语课件 |
| 英语试题 |
| 不限 |
| 不限 |
| 上册 |
| 下册 |
| 不限 |