Seth Rogen and Zac Efrons comedy film Neighbors has unseated Spider-Man at the top of the US box office.
The film, which is being released as Bad Neighbours in the US, sold $51m (£30.2m) of tickets over the weekend.
The Amazing Spider-Man 2, starring British actor Andrew Garfield, took $37m (£22m), according to estimates.
Cameron Diaz comedy The Other Woman held onto third place with Heaven Is for Real and Captain America: The Winter Soldier completing the top five.
Neighbors sees Rogen and Rose Byrne as new parents who find themselves engaged in a battle of wits when a rowdy fraternity house, led by a frequently shirtless Efron, moves in next door.
Paul Dergarabedian, senior media analyst for box-office tracker Rentrak said: You dont expect a comedy to be able to unseat an epic blockbuster, but historically it happens more than you think.
The sequel to The Amazing Spider-Man, which sees Garfield reprise his role as the web-slinging superhero, has made more than $550m (£326m) in worldwide ticket sales so far.
Christian drama Heaven Is for Real has been the surprise hit of the year so far. Telling the story of a four-year-old who says he experienced Heaven during emergency surgery, it has earned more than $75m (£44m) on an estimated budget of just $12m (£7m).
由赛斯罗根和扎克埃夫隆主演的喜剧电影《邻居大战》强势登顶挤下《超凡蜘蛛侠2》夺得美国票房冠军。
《邻居大战》在美国上映,整个周末赢得了5100万美元的票房。
据估计,由英国演员安德鲁加菲尔德主演的《超凡蜘蛛侠2》,赢得了3700万的票房。
卡梅隆迪亚兹的喜剧《另一个女人》排名第三,《真的有天堂》和《美国队长2:冬冰战士》分别排名第四和第五。
《邻居大战》讲述了一对初为父母的美国夫妇发现,一个由赤膊的埃夫隆领导的,吵闹的联谊会会堂搬到他们隔壁之后,他们之间就经常斗智斗勇。
资深媒体分析师德加拉伯迪安说:你不指望一个喜剧能够推翻史诗大片,但从历史上看,这种情况经常发生,而且比你想象的更多。
在《超凡蜘蛛侠2》中,加菲尔德重现会吐丝织网的超级英雄形象,到目前为止,取得了超过5.5亿美元全球票房的成绩。
基督教喜剧《天堂真实存在》是今年迄今为止最让人意外的一部电影,它讲述了一个4岁的孩子自称自己在做紧急手术去过了天堂的故事,赢得了超过7500万美元的票房,而它原本估计只有1200万美元。
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