澳大利亚新南威尔士大学的一位教授最近在抗衰老药物研究方面取得突破性进展,人类想要长生不老的愿望或许终有一天会成为现实。这位教授发现,人体内有一种抗衰老酶能够防止衰老性疾病,同时延长寿命。这位教授发现,他研究中使用的117种药物均通过相同的原理作用于这种酶。这一发现说明,研究人员可以通过深入研究研发出一种可以治疗某种重大疾病、同时防止其他多种疾病的药物,从而达到延缓衰老的目的。目前,一系列病理试验均显乐观,这种药物有望在2018年以前面世。
Man's search for immortality is another step closer to reality with a major breakthrough in creating a drug capable of fighting the aging process -- a drug that could be available before 2018 -- after pioneering work led by an Australian researcher with the University of New South Wales (UNSW).
The study led by Professor David Sinclair, from UNSW Medicine, has revealed that a single anti-aging enzyme in the body has the potential to prevent age-related diseases and extend lifespans.
The paper released this month, shows all of the 117 drugs tested work on the single enzyme through a common mechanism.
These consequences are far-ranging and suggest that an entirely new class of anti-aging drugs are now viable.
Drugs that could ultimately prevent the great diseases of our lifetime -- from cancer, Parkinson's Disease, Alzheimer's disease and even the burden of modern lifestyles -- type 2 diabetes.
"Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others," Professor Sinclair said.
"In effect, they would slow aging."
Trials focusing on a series of maladies have shown promise already, and the list is a veritable who's who of the great diseases of the 21st century.
"In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster," said Professor Sinclair, a geneticist with the Department of Pharmacology at UNSW.
The technology was sold to pharmaceutical giant GlaxoSmithKline in 2008.
Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed with the best three in human trials today.
"Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight," said Professor Sinclair, who has isolated diabetes as the first disease to be targeted.
There have been limited trials in people with type 2 diabetes with measurable benefits to the subject's metabolism.
Professor Sinclair hopes that one day, the drugs could be taken orally as a preventative.
Effectively, a pill that prevents the illnesses associated with natural aging.
In animal models, overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 percent longer.
"Now we are looking at whether there are benefits for those who are already healthy. Things there are also looking promising," said Professor Sinclair, who also heads the Lowy Cancer Research Centre's Laboratory for aging Research at UNSW.
"We're finding that aging isn't the irreversible affliction that we thought it was... Some of us could live to 150, but we won’t get there without more research."
英语六级听力短对话题的冲刺
英语六级对话类听力的冲刺
英语六级听力的高频词(I篇)
英语六级复合式听写填词分析与预测
12月英语六级考试听力填空高分技巧
英语听力151组容易混淆拼错单词
英语六级听力的高频词(B篇)
六级听力的解题指导(3)
12月六级听力模拟试题(一)
英语六级听力应试五边处理法
六级听力的解题指导(2)
12月六级考试A卷听力答案
英语六级听力高频词
英语六级强化班听力场景词汇的精要
六级考试听力填空考试的技巧
英语六级考试挑战710分之听力理解(五)
英语六级复合式听写分析预测
快速提高六级的听力
12月英语六级短文听写填句难关
英语六级考试听力训练原文
英语六级考试听力原文
英语六级考试听力小对话得分的原则
12月22日六级考试听力录音
6月六级听力测试答案
12月22日英语六级听力原文
全国英语六级历年真题及听力汇总
大学英语六级考试听力模拟试题(三)
6月英语六级考试听力成功指南(第十期)
大学英语六级听力考前听力训练
大学英语六级考试听力理解的综合辅导(二)
不限 |
英语教案 |
英语课件 |
英语试题 |
不限 |
不限 |
上册 |
下册 |
不限 |