H7N9发生变异将会导致有效的人传人

　　一项关于H7N9禽流感的重大研究25日在世界著名医学期刊《柳叶刀》的官方网站在线发表。这篇由中国科学家团队完成的研究论文首次在国际上警示，H7N9病毒正在向适合感染哺乳动物方向发展，这使病毒更容易感染到人。

　　Published a major study of H7N9 avian influenza in 25 days in the world famous medical journal "Lancet" official website online. This article is completed by the Chinese team of scientists study for the first time in the international warning, H7N9 virus to infect mammals are suitable for the direction of development, which make the virus more easily infected people.

　　同时，这一研究成果首次对外公布了一例感染患者和一例受感染禽类的全序列基因。并在全球首次报告，发现H7N9的重症感染者会出现类似SARS病毒感染的细胞因子风暴。

　　At the same time, this research first announced a case of infection and one case of infected poultry gene sequence. And the first report in the world, found H7N9's severe infections will be a cytokine storm similar to SARS virus infection.

　　记者从26日在杭州举行的资讯发布会上获悉，来自浙江大学、清华大学、香港大学和国家疾控中心的专家团队，共同完成了这一重要课题的研究和论文撰写。通过对发生在浙江的4例患者以及与他们可能有关的活禽市场中鸡、鸭、鹌鹑和鸽子的H7N9采样和分析，专家们发现，患者体内分离出的H7N9病毒与活禽市场中的鸡中分离到的病毒株基因序列高度同源。

　　Reporter from the 26 held in Hangzhou was informed of the news conference, the team of experts from the Zhejiang University, Tsinghua University, University of Hong Kong and the National Center for disease control, complete the research and thesis of this important topic to write. Through the sampling and analysis of occurred in 4 patients in Zhejiang and they may be related to the live bird markets of chicken, duck, quail and dove H7N9, the experts found that, H7N9 virus isolation and the live bird markets isolated from patients in the chicken strains of the virus gene sequences are highly homologous.

　　“这是我们首次通过实验证明、而非猜测，获得H7N9病毒从禽类向人类传播的证据。该团队的领导者、国家卫生和计生委人感染H7N9禽流感疫情防控工作专家组专家李兰娟院士说。

　　"This is the first time we proved by experiments, rather than speculation, obtain evidence H7N9 virus from birds to humans spread." The group leader, national health and Family Planning Commission of human infection with the H7N9 avian influenza epidemic prevention and control work expert group expert academician Li Lanjuan said.

　　不仅如此，研究团队在对病毒基因组研究后发现，病毒的H7基因中发生氨基酸位点发生变异，这使得病毒更容易从禽类感染到人。“如果PB2基因的627和701氨基酸位点同时发生变异，将会导致有效的人传人。论文这样表述。目前研究团队已发现了701位点的变异。

　　Not only that, the research team found that in the study of the viral genome, amino acid mutation of H7 gene in the occurrence of the virus, the virus more easily from birds to people. "If the PB2 gene were 627 and 701 amino acid sites at the same time change, will lead to efficient human-to-human transmission." The paper thus expressed. The research team has found that the variation of 701 loci.

　　此外，专家还对H7N9患者的发病特点进行了科学上的分析和解释。研究首次发现，H7N9病毒主要存在于下呼吸道，在患者的痰和下呼吸道灌洗液中表现出长时间的高阳性率，但在鼻咽拭子的病毒检测中，阳性的检出率和持续时间都较短。“这一成果对我们准确确诊和判断疫情，并开展有针对性的治疗具有指导意义。论文作者之一梁伟峰说。

　　In addition, the experts also to the clinical characteristics of patients with H7N9 were analyzed and interpreted on science. The studies show, H7N9 virus exists mainly in the lower respiratory tract, showed a high positive rate of long time in patients with lower respiratory tract sputum and lavage fluid, but in the detection of nasopharyngeal swab of the virus, the positive detection rate and duration are short. "The results of our accurate diagnosis and judgment of the epidemic, and carrying out targeted therapy has a guiding significance." One of the authors, said Liang Weifeng.

　　拥有190年历史的《柳叶刀》杂志是世界上最具影响力和权威性的医学期刊之一。除了在其网站的头条位置发表该论文全文外，该刊物还专门聘请了国际顶级病毒学权威、荷兰阿姆斯特丹大学的马里恩·科普曼斯教授撰文，对该论文的创新之处进行了评价。

　　With a history of 190 years, "the Lancet" magazine is the world's most influential and authoritative medical journal of. In addition to the headline position in its website published the thesis, the publication also specially invited Professor Marion Koopmans international top virology authority, University of Amsterdam in Holland wrote, the innovation of the paper is evaluated.