Three-time finalist Andy Roddick was stunned in the fourth round at Wimbledon on Monday by unhearlded Lu Yen-Hsun of Chinese Taipei.
The fifth-seeded American went down 4-6, 7-6 (3), 7-6 (4), 6-7 (5), 9-7 in a match that lasted over 4 hours.
The 26-year-old Lu, who had lost in the first round at Wimbledon four straight times, became the first Asian man to reach the quarterfinals of any Grand Slam since Shuzo Matsuoka of Japan did it at Wimbledon in 1995.
Lu, ranked 82 in the world, said he didn't believe he could win but told himself to keep fighting.
"I just told myself, 'If I can stay longer, longer, longer, then probably something happens'," he said. "And finally then I waited for the last chance to close the match."
Earlier, defending women's champion Serena Williams overcame Maria Sharapova 7-6 (11-9), 6-4 to reach the quarterfinals and avenge her loss to the Russian in the 2004 final.
Kim Clijsters rallied to beat Justine Henin 2-6, 6-2, 6-3 in an all-Belgian duel between former No. 1-ranked players making Wimbledon comebacks after returning from retirement.
Meanwhile, defending champion Roger Federer, 2008 champion Rafael Nadal, third-seeded Novak Djokovic, No. 4 Andy Murray and five-time women's winner Venus Williams also advanced on an action-packed day featuring all remaining 32 men's and women's players in fourth-round matches.
Federer, chasing a record-tying seventh Wimbledon singles title, swept past 16th-seeded Jurgen Melzer 6-3, 6-2, 6-3 to reach his 25th consecutive Grand Slam quarterfinal.
Nadal beat Paul-Henri Mathieu 6-4, 6-2, 6-2, and next faces sixth-seeded Robin Soderling, the Swede who beat him in the fourth round at the French Open last year. Nadal beat Soderling in last month's French Open final.
Soderling, who hadn't dropped a set until Monday, needed five sets to beat No. 9 David Ferrer 6-2, 5-7, 6-2, 3-6, 7-5 to make the quarters for the first time.
Djokovic beat 2002 champion Lleyton Hewitt 7-5, 6-4, 3-6, 6-4 to reach the quarterfinals for the second year in a row.
Murray swept past American Sam Querrey 7-5, 6-3, 6-4 to reach the final eight for the third consecutive year.
Murray, seeking to become the first British player to win the men's singles title since Fred Perry in 1936, will next meet 10th-seeded Frenchman Jo-Wilfried Tsonga.
Vera Zvonareva advanced when fourth-seeded Jelena Jankovic retired with a back injury while trailing 6-1, 3-0. The Russian will next face Clijsters.
Third-seeded Caroline Wozniacki lost 6-2, 6-0 to unseeded Czech Petra Kvitova.
Also making the quarters were No. 9 Li Na of China, Tsvetana Pironkova of Bulgaria and qualifier Kaia Kanepi of Estonia.
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