FC Barcelona kicks off match day 30 in Spain's Primera Liga with a home game against Recreativo Huelva on Saturday night. Barcelona plays hot on the heels of the 4-0 thrashing of Bayern Munich in the Champions League on Wednesday night and coach Pep Guardiola will be hoping his players do not feel the effects of tiredness.
He will probably make some changes to his side with young striker Bojan Krkic given his chance along with midfielder Seydou Keita.
Recreativo Huelva meanwhile travels to town in deep trouble. The club's defeat last weekend against Sevilla has seen Lucas Alcaraz's outfit drop into the bottom three. Failure to take a point from the Camp Nou could see a gap start to open between them and safety.
Real Madrid plays at home against Valladolid. Madrid has not played in Europe, but coach Juande Ramos has fitness doubts over midfielders Arjen Robben and Marcelo, as well as central defender Pepe.
Should Barcelona win its game on Saturday night, Madrid will kick off nine points behind the league leaders and cannot afford to fail.
Sevilla plays at home to Getafe and Manolo Jimenez's team is favorite to take all three points against a team in serious trouble.
Defeat in Valencia saw Getafe drop to within one point of the relegation zone and a setback in the Sanchez Pizjuan stadium could see coach Victor Munoz facing the sack.
Oscar Ustari returns in goal for Getafe following Jacobo's red card last Sunday.
There is a tight race for fourth place in the table between Villarreal, Valencia and Atletico Madrid. Five points separate the three sides that have a chance of making the last Champions Leaguespot.
Villarreal has a difficult game at home to seventh placed Malaga and Manuel Preciado's team needs to recover from a 1-1 Champions League draw against Arsenal.
Valencia travels to play Sporting Gijon with striker David Villa making an emotional return to the club where he began his career. Meanwhile an irregular Atletico Madrid visits Deportivo laCoruna.
The week also sees drama at the bottom of the Primera Liga. Second from bottom Numancia entertains bottom side Espanyol in a match that is make or break for both teams' hopes of avoiding relegation.
Osasuna and Athletic Bilbao can both take a huge step towards safety in the Reino de Navarra stadium, while new Betis coach Jose Nogues makes his debut away to Racing Santander.
Finally Mallorca plays away to Almeria.
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